FIGURE 1.

(A) Acetylcholine- (Ach, 16.6 mg/kg, dissolved in 50 μl pyrogen-free saline administered intraperitoneally) and (B) flow-dependent dilation in endo-αENaC^KO and control mice in basal conditions (saline) and in endotoxemia (LPS, 10 mg/kg, i.p., 12 h) assessed in vivo by MRI. Ach-dependent dilation was measured in TA while flow-dependent dilation was determined in FA, control (saline) n = 4, endo-αENaC^KO (saline) n = 5, control (LPS) n = 7–9, endo-αENaC^KO (LPS) n = 5–7. Statistics: one-way ANOVA followed by Tukey’s post hoc test (normality was assessed using the Kolmogorov–Smirnov test). The results are presented as the mean ± SEM, ^∗p < 0.05, ^∗∗p < 0.01.