FIGURE 3.

Changes in fluorescence intensity in homogenates of perfused organs: (A) lungs, (B) liver (C–F) blood–brain barrier (BBB) in endo-αENaC^KO and control mice in basal conditions (saline) and in endotoxemia (10 mg/kg, i.p., 12 h). EB was administered as the contrast agent (4 mg/ml, i.v.), control (saline) n = 14–32, endo-αENaC^KO (saline) n = 5–12, control (LPS) n = 13–30, endo-αENaC^KO (LPS) n = 9–36. Statistics: for hippocampus, brainstem: one-way ANOVA followed by Tukey’s post hoc test; for lung, liver, cerebral cortex, cerebellum: Kruskal–Wallis test followed by Dunn’s post hoc test (normality was assessed using the Kolmogorov–Smirnov test). The results are presented as the median with interquartile range, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001; ^∗∗∗p < 0.0001.