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Schematic representation of OPTN protein structure, interaction partners, and most common POAG- and ALS-associated mutations (indicated in red). Abbreviations: ALS, amyotrophic lateral sclerosis; CC, coiled coil; CYLD, cylindromatosis; E3-14.7K, early region 3 14.7 kDa protein; LIR, LC3-interacting region; POAG, primary open-angle glaucoma; RIPK1, receptor-interacting protein kinase 1; TBK1, TANK-binding kinase 1; UBD; ubiquitin-binding domain; ZF, zinc finger; OPTN, optineurin.
