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. 2018 Apr 16;8:6030. doi: 10.1038/s41598-018-24463-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The construction of 3B12A intrabodies against misfolded TDP-43. (a) DNA and peptide sequences of VH (left panel) and VL (right panel). VH contains residues with high PEST score, thus referred to as a PEST-like sequence, in the CDR2 domain. (b) Domain profiles of 3B12A intrabodies. After cloning cDNAs encoding variable fragments of the heavy chain (VH) and light chain (VL) from a hybridoma expressing 3B12A IgG, we constructed plasmids encoding single-chain variable fragments (scFv) as 3B12A intrabodies with Myc-tag.