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. 2018 Apr 16;8:6041. doi: 10.1038/s41598-018-24379-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene clustering of single-depth PPI network of pcPSGs and gene ontology (GO) term summarisation of gene clusters. (a) Gene clusters of nine subnetworks are shown in different colours. The colour indicator is located in the top right corner. The genes that are not in subnetworks are grey colour. (b) GO term summary of gene clusters of subnetworks are presented as a tree map. The name of the subnetwork is on top of the tree map, and the relative size of blocks shows the significance of enrichment of the GO term. Similar GO terms were combined and grouped into a large block of the same colour. The term of most uniqueness in the large block is shown on the white box and located at the centre of the block.