Table 3.
Presence of genotoxic or pro-inflammatory genes of the three cohorts selected for this analysis, i.e., Healthy, Crohn’s disease and Ulcerative colitis.
| Healthy cohort (N = 251) |
Crohn’s disease cohort (N = 60) |
Ulcerative colitis cohort (N = 17) |
||||
|---|---|---|---|---|---|---|
| Genes (p-values)a | Positives (M/F) | Frequency % | Positives | Frequency % | Positives | Frequency % |
| AMmurB (0.3026) | 25 (11M + 14F)b | 10 | 4 | 7 | 0 | 0 |
| usp (2 × 10-5) | 13 (8M + 5F) | 5 | 6 (2M + 4F) | 10 | 6 (6M)d | 35 |
| tcpC (0.7031) | 7 (4M + 3F) | 3 | 1 | 2 | 0 | 0 |
| cnf-1 (0.0081) | 2 (2F) | 0.8 | 4 | 7 | 0 | 0 |
| gelE (2 × 10-7) | 2 (2M) | 0.8 | 9 (3M + 6F) | 15 | 0 | 0 |
| cif (0.0154) | 1 (1F) | 0.4 | 0 | 0 | 1 | 6 |
| clbB (0.4978) | 1 (1F) | 0.4 | 1 | 2 | 0 | 0 |
| clbN (0.0922) | 1 (1M) | 0.4 | 2 | 3 | 0 | 0 |
| Totalb | 40c | 16% | 19c | 31% | 6c | 29% |
Columns represent: gene names, number of samples with hits (positives) and the corresponding frequency of samples with gene hits per study cohort. aP-value for the differences between the number of samples with and without gene hits across the three studied cohorts (Khromov-Borisov et al., 1999). b11 males and 14 females positive for the presence of this gene. cTotal number of individuals positive for at least one gene. Some had more than one gene. dThe ulcerative colitis cohort consisted of 16 males and one female.