Table 4.

Unadjusted scores of patient-reported outcomes by immediate (n = 1639) and delayed (n = 147) timing.

PRO measure	Timing	Pre-op			Two years post-op
		na	Mean (SD)	p-Valueb	na	Mean (SD)	p-Valueb
BREAST-Q: Satisfaction with breast	Immediate	1632	62.8 (21.1)	<0.001	1073	65.1 (18.1)	0.559
	Delayed	147	34.0 (16.3)		96	66.2 (20.6)
BREAST-Q: Psychosocial well-being	Immediate	1631	70.9 (17.9)	<0.001	1065	74.4 (19.0)	0.159
	Delayed	147	51.9 (15.1)		96	77.3 (21.4)
BREAST-Q: Physical well-being	Immediate	1632	78.5 (14.7)	<0.001	1061	76.3 (14.8)	0.870
	Delayed	147	72.0 (14.3)		96	76.0 (14.4)
BREAST-Q: Sexual well-being	Immediate	1585	57.5 (19.1)	<0.001	1026	54.8 (21.4)	0.823
	Delayed	146	31.6 (19.4)		89	54.3 (23.5)
PROMIS: Physical function	Immediate	1635	53.0 (6.7)	<0.001	1049	51.8 (6.8)	0.276
	Delayed	146	50.0 (7.5)		93	51.0 (7.4)
PROMIS: Anxiety	Immediate	1635	58.9 (8.8)	<0.001	1048	49.7 (9.0)	0.024
	Delayed	146	52.1 (9.7)		94	47.5 (9.4)
PROMIS: Depression	Immediate	1635	49.8 (8.4)	0.852	1047	46.8 (7.8)	0.383
	Delayed	146	49.7 (9.1)		94	46.1 (7.4)
PROMIS: Fatigue	Immediate	1635	49.8 (9.9)	0.938	1044	48.3 (10.0)	0.477
	Delayed	146	49.8 (9.5)		94	49.1 (10.9)
PROMIS: Sleep disturbance	Immediate	1632	52.0 (3.5)	0.112	1046	52.1 (3.9)	0.102
	Delayed	146	52.5 (3.4)		94	52.8 (3.8)
PROMIS: Satisfaction with participation in social roles	Immediate	1635	51.8 (9.5)	0.060	1046	52.9 (9.7)	0.760
	Delayed	146	50.3 (9.5)		93	53.2 (10.9)
PROMIS: Pain interference	Immediate	1635	45.9 (7.3)	<0.001	1047	46.4 (7.8)	0.072
	Delayed	146	48.6 (8.3)		93	47.9 (8.5)
EORTC: Body image	Immediate	1622	79.8 (23.0)	<0.001	1042	75.3 (24.6)	0.971
	Delayed	146	43.0 (30.1)		93	75.4 (26.1)
EORTC: Sexual functioning	Immediate	1614	32.0 (24.4)	0.035	1037	31.7 (24.6)	0.229
	Delayed	147	27.6 (25.0)		94	28.5 (25.4)

^aThe number of patients with complete PRO.

^bFor the comparison of preoperative PROs between immediate and delayed group.