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Examples of compounds targeting bacterial chaperones. Representative structures are shown of (a) small molecules or (b) amino acid sequences of proline-rich peptides that inhibit bacterial GroEL/ES, HtpG, and DnaK. Some proline-rich peptides like Bac-7 and pyrrhocoricin may mediate antibacterial activity by inhibiting translation. To date, there are no examples of compounds or peptides targeting mycobacterial protein folding machinery.
