Fig. 3.

a Relative position of frameshift, non-frameshift indels, and stop-gained variants. Frameshift variants are enriched in N- and C-terminal parts of the protein. Frameshift variants at the N-terminal sites are potentially “rescued” by alternate start-codons. Frameshift variants at the C terminal end are likely not disruptive since a functional protein might still be translated. b Distribution of lengths of coding and non-coding indels. In-frame indels (i.e. indels with lengths of 3, 6, and 9 nucleotides) are enriched in coding regions