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. 2018 Apr 16;18:430. doi: 10.1186/s12885-018-4304-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — CDKN1C-E2F1-TP53 axis in T-LBL development. Having in mind the consequences of alterations in these genes in mouse models [11, 34], T-LBLs in our samples series might be classified into different categories. a In normal cells CDKN1C regulates E2F1 to control the expression of E2F target genes and the activity of TP53 during thymocyte development. b Decreasing of CDKN1C (due to epigenetic mechanisms and/or upregulation of specific miRNAs) could lead to proliferation, that may be favoured by overexpression of E2F1 (through downregulation of specific miRNAs). c The additional impairment of TP53 (by the combined effect of inactivating mutations, differential expression of isoforms, and/or deregulation of specific miRNAs) should lead T-cell lymphoblastic neoplasia development