Table 1.
Baseline Characteristics of Study Participants in the Cohort Random Sample by Tertiles of NT-proBNP
| Brain Natriuretic Peptide (N-terminal pro BNP), tertiles of pg/mL | ||||
|---|---|---|---|---|
| Characteristics* | < 42.5 | 42.5–115.5 | ≥115.5 | p-value † |
| Total participants, n | 278 ‡ | 280‡ | 289‡ | |
| Male, n (%) | 168 (60.4) | 119 (42.5) | 101 (35.0) | < 0.001 |
| African American, n (%) | 168 (56.8) | 129 (46.1) | 142 (49.1) | 0.03 |
| Age in years, mean (SD) | 59.7 ± 9.5 | 65.9 ± 11.2 | 74.5 ± 10.9 | < 0.001 |
| Less than High School education, n (%) | 28 (10.1) | 38 (13.6) | 61 (21.1) | 0.001 |
| Annual Income, n (%) | 0.001 | |||
| < $20,000 | 38 (13.7) | 46 (16.4) | 71(24.6) | |
| ≥$20,000 | 208 (74.8) | 193 (68.9) | 157 (54.3) | |
| Declined to report | 32 (11.5) | 41 (14.6) | 61 (21.1) | |
| Current smoking, n (%) | 46 (16.6) | 41 (14.7) | 33 (11.5) | 0.21 |
| Systolic blood pressure, mmHg, mean (SD) | 125 ± 14.8 | 127 ± 17.4 | 130.8 ± 18.0 | < 0.001 |
| High density lipoprotein, mg/L, mean (SD) | 50.0 ± 14.7 | 53.1 ± 17.0 | 54.0 ± 18.7 | 0.005 |
| Total cholesterol, mg/L, mean (SD) | 196 ± 41 | 192 ± 37 | 186 ± 37 | < 0.001 |
| Diabetes, n (%) | 52 (19.1) | 49 (17.8) | 59 (20.6) | 0.67 |
| Body mass index, kg/m2, mean (SD) | 29.8 ± 5.7 | 29.1 ± 6.5 | 27.6 ± 5.5 | < 0.001 |
| C-reactive protein mg/L, median (IQR) | 1.9 [0.9–5.0] | 2.1 [0.9–4.7] | 2.2 [1.1–4.7] | 0.37 |
| Urinary albumin-to-creatinine ratio > 30 mg/g, n (%) | 14 (5.1) | 30 (11.2) | 65 (23.6) | < 0.001 |
| Estimated glomerular filtration mL/min/1.73 m2 rate < 60§, n (%) | 10 (3.6) | 25 (9.0) | 70 (24.5) | < 0.001 |
| Use of hypertensive medication, n (%) | 112 (40.4) | 128 (45.9) | 173 (60.5) | < 0.001 |
| Use of statins, n (%) | 73 (26.5) | 69 (24.9) | 78 (27.2) | 0.82 |
| Regular use of aspirin, n (%) | 97 (35.0) | 95 (34.0) | 117 (40.6) | 0.21 |
* Characteristics within the cohort random sample; missing values included use of statins (n = 7), use of hypertensive medication (n = 5), estimated glomerular filtration rate (eGFR) (n = 7), baseline diabetes (n = 11), C-reactive protein (n = 23), aspirin use (n = 2), urinary albumin-to-creatinine ratio (n = 32), systolic blood pressure (n = 5), high density lipoprotein (n = 13), cholesterol (n = 7), and body mass index (n = 7). † P-values from analysis of variance for continuous variables and Pearson chi square for categorical variables. ‡ Data weighted to the full cohort for analysis. Tertiles based off of weighted sample. § eGFR < 60 mL/min/1.73 m2 = chronic kidney disease (CKD)