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. 2018 Apr 16;18:426. doi: 10.1186/s12885-018-4347-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — IR-induced micronuclei in OVCAR-8 cells are associated with aberrant mitosis. a-b: Representative images (a) and quantification (b) of abnormal mitoses in post-IR OVCAR-8 cells. Normal and aberrant mitosis were visualized by DAPI. Red arrows: lagging or broken chromosomes. n = 3 biological repeats. Error bars = s.d. ***P < 0.001 (t-test). c: Localization of γH2AX associated with broken chromosomes of mitotic cells (red arrows) or MN aside post-mitotic nucleus (white arrows). d-e: Enumeration of MN formation (Left vertical axis) and mitotic index (Right vertical axis) and in OVCAR-8 (d) and SKOV-3 (e) cells at 12 intervals after IR treatment (2 Gy). Both cell lines showed increased post-IR MN formation correlated with earlier changes mitotic index