Table 1.
Summarization of clinical and pathologic characteristics of entire patients and according to the up-staging of pathologic stages after surgical treatments for clinical stage T1 renal cell carcinoma
| Entire patients (n = 3431) |
Patients without up-staging (n = 3216) |
Patients with up-staging (n = 215) |
p value | |
|---|---|---|---|---|
| Preoperative characteristics | ||||
| Median Age (y) | 55.0 (46.0–65.0) | 55.0 (46.0–65.0) | 60 (52.0–69.0) | < 0.001 |
| Median BMI (kg/m2) | 24.6 (22.6–26.7) | 24.6 (22.6–26.7) | 24.4 (22.7–26.7) | 0.406 |
| Gender (male) | 2462 (72%) | 2304 (72%) | 158 (74%) | 0.585 |
| ECOG score (≥1) | 802 (23%) | 749 (23%) | 53 (25%) | 0.677 |
| Diabetes mellitus | 502 (15%) | 459 (14%) | 43 (20%) | 0.028 |
| Hypertension | 1351 (40%) | 1244 (39%) | 107 (50%) | 0.001 |
| Tumour size (cm) | 3.3 (2.0–4.4) | 3.1 (1.9–4.1) | 5.0 (3.7–6.2) | < 0.001 |
| Laparoscopy | 1420 (41%) | 1355 (42%) | 85 (40%) | 0.617 |
| Type of nephrectomy | < 0.001 | |||
| Radical | 1360 (40%) | 1202 (37%) | 158 (74%) | |
| Partial | 2071 (60%) | 2014 (63%) | 57 (27%) | |
| Hilar location | 210 (6.1%) | 174 (5.4%) | 36 (17%) | < 0.001 |
| Tumour location | 0.204 | |||
| Exophytic | 1678 (49%) | 1565 (49%) | 113 (53%) | |
| Mesophytic | 809 (24%) | 769 (24%) | 40 (19%) | |
| Endophytic | 944 (28%) | 882 (27%) | 62 (29%) | |
| Clinical stages | < 0.001 | |||
| cT1a | 2462 (72%) | 2379 (74%) | 83 (39%) | |
| cT1b | 969 (28%) | 837 (26%) | 132 (61%) | |
| Postoperative characteristics | ||||
| Pathologic stage | < 0.001 | |||
| pT1 | 2406 (70%) | 2406 (75%) | ||
| pT2 | 810 (24%) | 810 (25%) | ||
| pT3a | 215 (6.3%) | 215 (100%) | ||
| Fuhrman grade | < 0.001 | |||
| ≤2 | 1935 (56%) | 1865 (58%) | 70 (33%) | |
| ≥3 | 1496 (44%) | 1351 (42%) | 145 (67%) | |
| Histologic subtype | 0.234 | |||
| Clear cell | 2912 (85%) | 2737 (85%) | 175 (81%) | |
| Papillary | 238 (6.9%) | 223 (6.9%) | 15 (7.0%) | |
| Chromophobe | 236 (6.9%) | 217 (6.7%) | 19 (8.8%) | |
| Collecting duct | 6 (0.2%) | 5 (0.2%) | 1 (0.5%) | |
| Unclassified | 39 (1.1%) | 34 (1.1%) | 5 (0.1%) | |
BMI body mass index, ECOG Eastern Cooperative Oncology Group