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. 2018 Apr 16;18:58. doi: 10.1186/s12935-018-0546-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — HO-8910PM cells were cultured with ONC-V3 for 48 h. The blank control group and the group of 0.05 μmol/L were basically healed. The number of neonatal tumor cells in the original scratches was slightly greater than on the scratches. The scratches in the 0.20 and 0.40 μmol/L groups were not significantly healed, indicating that high concentrations of Onc-V3 could inhibit tumor cell migration and healing. The recombinant immune toxin Onc-V3 was found to inhibit the migration ability of highly metastatic human ovarian cancer cells of strain HO-8910PM, and this ability was dose-dependent