Table 2.
Genome-wide and chromosome-wise significant SNPs and associated genes.
| Population | SNP | Chr | Position (bp) | MAF | p-unadjusted | p-adjusted | Genes | Location |
|---|---|---|---|---|---|---|---|---|
| Wadi | rs416717560∗ | 6 | 29295803 | 0.07 | 3.65E-08 | 8.19E-09 | BMPR1B1 | 3′UTR |
| rs421635584∗ | 6 | 29361782 | 0.05 | 4.36E-06 | 9.78E-07 | BMPR1B1 | Intron | |
| rs429416173 | 6 | 29302788 | 0.2 | 7.55E-05 | 2.75E-05 | BMPR1B1 | CDS | |
| rs402803857 | 7 | 58598895 | 0.1 | 4.96E-05 | 2.93E-05 | FBN11 | Intron | |
| rs160917020∗ | 14 | 23133427 | 0.19 | 1.10E-06 | 3.71E-07 | MMP2 | Downstream | |
| Hu | rs429755189∗ | 17 | 41621298 | 0.43 | 1.94E-06 | 3.21E-07 | GRIA21 | Intron |
| rs420460180 | 17 | 41621269 | 0.29 | 8.50E-06 | 2.43E-06 | GRIA21 | Intron | |
| rs406357666 | 17 | 12487861 | 0.19 | 1.40E-05 | 2.66E-05 | SMAD11 | Intron | |
| rs427436644 | 19 | 13639996 | 0.32 | 7.69E-05 | 2.14E-05 | CTNNB1 | Downstream | |
| rs412185353 | 19 | 13641870 | 0.33 | 1.51E-04 | 4.49E-05 | CTNNB1 | Downstream | |
| Icelandic | rs429836421 | 3 | 32030054 | 0.16 | 4.55E-05 | 3.63E-05 | NCOA11 | Intron |
| Finnsheep | rs412280524∗ | 2 | 184578329 | 0.09 | 2.62E-05 | 5.32E-07 | INHBB | Downstream |
| rs401960737∗ | 2 | 184579671 | 0.09 | 2.62E-05 | 5.32E-07 | INHBB | Downstream | |
| rs160509574 | 10 | 31933001 | 0.27 | 1.50E-05 | 4.71E-05 | FLT11 | Intron | |
| rs417444297 | 11 | 18552961 | 0.11 | 4.20E-05 | 5.65E-05 | NF1 | Downstream | |
| rs404890873 | 12 | 65662842 | 0.05 | 1.87E-04 | 1.59E-05 | PTGS2 | Upstream | |
| rs401746929 | 21 | 41915064 | 0.08 | 1.85E-03 | 1.75E-04 | PLCB3 | Upstream | |
| rs402764237 | 21 | 41919836 | 0.08 | 1.85E-03 | 1.75E-04 | PLCB3 | Upstream | |
| Romanov | rs423810437∗ | 7 | 73335157 | 0.07 | 1.65E-05 | 3.12E-06 | ESR21 | 5′ flanking region |
| Texel | rs409969387 | 8 | 75353388 | 0.08 | 1.11E-03 | 1.21E-04 | ESR1 | Intron |
| rs410595930 | 14 | 23645021 | 0.06 | 1.33E-04 | 1.46E-04 | SPP11 | Intron | |
| rs401207152 | 14 | 25147418 | 0.06 | 1.33E-04 | 1.46E-04 | MMP15 | Downstream | |
| rs161146164 | 16 | 31834495 | 0.06 | 1.33E-04 | 9.11E-06 | GHR1 | CDS | |
| rs413776054 | 16 | 31834942 | 0.06 | 1.33E-04 | 9.11E-06 | GHR | CDS | |
| rs426666828 | 16 | 31882869 | 0.18 | 1.88E-04 | 7.54E-05 | GHR1 | Intron | |
| rs413148060 | 21 | 30950537 | 0.15 | 1.02E-04 | 4.17E-05 | ETS1 | Upstream | |
| rs405994606 | 21 | 31001548 | 0.15 | 1.02E-04 | 4.17E-05 | ETS11 | Intron | |
| rs161612044 | 21 | 31009743 | 0.14 | 5.41E-04 | 1.01E-04 | ETS11 | Intron | |
| rs412251543 | 21 | 31178275 | 0.1 | 4.01E-03 | 1.46E-04 | ETS1/FLI1 | Upstream/Downstream |
For genes the best SNP of which is located outside of upstream/downstream 150 kb region. Chr., chromosome; MAF, Minor Allele Frequency. The p-unadjusted corresponds to exact p for the Fisher’s test. The p-adjusted corresponds to the corrected significance of GWAS after principle component adjustment. The SNPs with symbol (∗) denote that bonferroni-corrected genome-wide significant SNPs. The genes with symbol (1) denote that the SNPs are intragenic, otherwise they are the nearest genes upstream and downstream of the tested SNPs.