Table 2.

Correlations of ZG16 expression with clinicopathological features of colorectal cancer (TCGA COAD dataset)

Clinical-pathological features		Number of cases	Gene expression (average)	P
Gender
	male	94	0.512	0.037
	female	99	− 0.487
Colon polyps present
	yes	73	−0.768	0.246
	no	129	−1.109
Anatomic neoplasm subdivision
	ascending colon	86	0.499	0.020
	descending colon	20	1.681
Histological type
	adenocarcinoma	62	−0.98	0.244
	mucinous- adenocarcinoma	385	−0.41
Lymphatic invasion
	yes	77	−1.136	0.793
	no	175	−1.032
Pathological-N	N2 N0	48,167	− 1.464 -0.806	0.0072
Hyper-mutation status
	true	32	−1.23	0.018
	false	119	0.571
Microsatellite instability status
	MSI-H	25	−1.58	0.037
	MSI-L	25	1.13
	MSS	98	0.491
MLH1 silencing
	yes	20	−1.143	0.043
	no	120	0.563
CpG island methylator phenotype
	CIMP-H	29	−0.74	0.38
	CIMP-L	35	−0.24
Treatment success status
	complete remission	92	−0.49	0.080
	progressive	28	−1.91
Sample type
	primary tumor	286	−1.61	0.000
	tissue normal	46	14.59