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. 2018 Apr 17;11:17. doi: 10.1186/s13072-018-0188-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of SIN3 isoforms in different species. This schematic was generated using the batch-CD (conserved domain) search interface from NCBI [67, 68]. The scale at the top represents amino acid positions in the protein. PAH domains are paired amphipathic helix domains involved in protein–protein interaction. HDAC interaction domain (HID), also known as Sin3 family corepressor domain, is involved in interaction with HDACs. Sin3a_C domain is a conserved domain found in the SIN3 protein family at the C-terminus, downstream of the Sin3 family corepressor domain. This region contains a protein–protein interaction domain and a region of high sequence conservation with unknown function, previously known as PAH4 and HCR, respectively. D.m., Drosophila melanogaster, M.m., Mus musculus