Table 3.
Multivariate Cox regression analysis of progression-free and overall survival
| Covariate | Progression-free survival | Overall survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 95 % CI | 95 % CI | |||||||||
| Coefficient | HR | Lower | Upper | p-value | Coefficient | HR | Lower | p-value | ||
| (B) | Exp(B) | (B) | Exp(B) | |||||||
| age (continous, unit: 1 year) | 0.008 | 1.009 | 0.99 | 1.02 | 0.254 | 0.04 | 1.04 | 1.02 | 1.06 | *<0.001 |
| pT2-4, reference category: pT1 | -0.879 | 0.42 | 0.28 | 0.62 | *<0.001 | -1.17 | 0.31 | 0.19 | 0.52 | *<0.001 |
| pN1-3, reference category: pN0 | -0.21 | 0.81 | 0.53 | 1.23 | 0.323 | -0.44 | 0.64 | 0.38 | 1.10 | 0.107 |
| ER pos, reference category: ER neg | 0.52 | 1.69 | 1.08 | 2.63 | *0.021 | 0.75 | 2.11 | 1.19 | 3.74 | *0.011 |
| PR pos, reference category: ER neg | n.i. | 0.56 | 1.75 | 1.03 | 2.98 | *0.040 | ||||
| HER2 pos, reference category: HER2 neg | n.i. | -0.57 | 0.57 | 0.31 | 1.04 | 0.067 | ||||
| EP3 pos, reference category: EP3 neg | 0.59 | 1.81 | 1.22 | 2.67 | *0.003 | 0.77 | 2.16 | 1.32 | 3.53 | *0.002 |
| number of samples | 275 | 275 | ||||||||
| number of events | 108 | 72 | ||||||||
HR hazard ratio, CI confidence interval, Pos positive, Neg negative, n.i. not included in multivariate model, as p>0.10 in bivariate analysis, *statistically significant (p-value < 0.05)