Table 1.

AOP-related documents published by the OECD

Category	Year	Title
Series on testing and assessment	2012	The AOP for skin sensitization initiated by covalent binding to proteins (series on Testing and Assessment No. 168)
	2013	Guidance document on developing and assessing AOPs (series on Testing and Assessment No. 184)
Series on AOPs	2016	Users' handbook supplement to the guidance document for developing and assessing AOPs (OECD series on AOPs No. 1)
	2016	AOP on protein alkylation leading to liver fibrosis (OECD series on AOPs No. 2)
	2016	AOP on alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations (OECD series on AOPs No. 3)
	2016	AOP on aromatase inhibition leading to reproductive dysfunction (in fish) (OECD series on AOPs No. 4)
	2016	AOP on chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development induces impairment of learning and memory abilities (OECD series on AOPs No. 5)
	2016	AOP on binding of agonists to ionotropic glutamate receptors in adult brain leading to excitotoxicity that mediates neuro nal cell death, contributing to learning and memory impairment (OECD series on AOPs No. 6)

AOP, adverse outcome pathway; OECD, Organization for Economic Cooperation and Development.