. 2018 Apr 15;34(2):85–95. doi: 10.5487/TR.2018.34.2.085

Table 6.

Lesion scores of liver and kidney of Sprague Dawley rats in subacute oral toxicity of ethanolic extract of Mariposa christia vespertilionis

Organ	Mean score of lesions	Control	Vehicle	Low dose (430 mg)	Medium dose (700 mg)	High dose (1480 mg)	Kruskal Wallis test for global comparison of organ lesions among groups asymptotic significant (p < 0.05)
Scored and Percentage of area affected (mm²)

Liver	Activated Kupffer cell	0^a	0^a	28.35 ± 0.20^ab	39.09 ± 0.20^b	39.09 ± 0.20^b	0.41
	Necrosis (karyolysis and eosinophilic cytoplasm)	0^a	0^a	50.5 ± 0.25^b	84.37 ± 0.11^c	126.55 ± 0.18^d	0.01*
	Necrosis (Pyknotic cells)	0^a	0^a	0^a	11.50 ± 0.17^b	11.50 ± 0.17^b	0.54
	Degeneration (vacuolated cytoplasm)	0^a	0^a	45.16 ± 0.21^b	28.35 ± 0.20^a	33.75 ± 0.18^a	0.08
	Regeneration	0^a	0^a	45.16 ± 0.21^b	45.16 ± 0.21^c	33.75 ± 0.22^d	0.01*
	Inflammation	0^a	0^a	11.48 ± 0.17^b	33.75 ± 0.22^c	45.16 ± 0.21^d	0.03*
	Mean score	0	0	36.13 ± 0.21	40.37 ± 0.19	48.25 ± 0.19	0.13

Kidney	Granular cast	0^a	0^a	0^a	0^a	0^a	1.00
	Cellular cast	0^a	0^a	0^a	0^a	0^a	1.00
	Protein cast	0^a	0^a	0^a	0^a	0^a	1.00
	Necrosis (Pyknotic cell)	0^a	0^a	0^a	0^a	0^a	1.00
	Inflammation	0^a	0^a	0^a	0^a	0^a	1.00
	Hydropic degeneration	0^a	0^a	0^a	0^a	0^a	1.00
	Mean score	0	0	0	0	0	1.00

The symbol * denotes the values were significantly different from control (p < 0.05).

^a,b,c

Indicate values in the same row with different superscript letters were significantly different (p < 0.05; Mann Whitney test).

0 mm²: none, < 33.75 mm²: less than 15%, < 67.49 mm²: 15~30%, < 101.24 mm²: 30~45%, < 134.99 mm²: 45~60%, < 168.74 mm²: 60~75% and > 168.74 mm²: more than 75%.