Table 7.

Lesion scores based on area affected in liver of Sprague Dawley rats in subacute oral toxicity of ethanolic extract of Mariposa christia vespertilionis

Organ	Area	Control	Vehicle	Low dose (430 mg)	Medium dose (700 mg)	High dose (1480 mg)	Kruskal Wallis test for global comparison of organ lesions among groups asymptotic significant (p < 0.05)
Scored and Percentage of area affected (mm2)
Liver	Centrilobular zonal	0.00 ± 0.00a	0.00 ± 0.00a	33.75 ± 0.22b	11.48 ± 0.17b	0.00 ± 0.00a	0.05*
	Midzonal	0.00 ± 0.00a	0.00 ± 0.00a	45.16 ± 0.21b	33.75 ± 0.22c	45.16 ± 0.21b	0.02*
	Periportal zonal	0.00 ± 0.00a	0.00 ± 0.00a	55.94 ± 0.28b	78.97 ± 0.25c	84.37 ± 0.25d	0.01*
	Mean	0.00 ± 0.00	0.00 ± 0.00	45.16 ± 0.24	41.11 ± 0.21	43.14 ± 0.15	0.03*

The symbol * denotes the values were significantly different from control (p < 0.05).

^a,b,c,dIndicate values in the same row with different superscript letters were significantly different (p < 0.05; Mann Whitney test).

0 mm²: none, < 33.75 mm²: less than 15%, < 67.49 mm²:15~30%, < 101.24 mm²: 30~45%.