Figure 3.

Influence of correlation between hepatic CYP3A4 and CYP2C8 on the prediction of systemic clearance (A), oral clearance (B) of repaglinide, and the fraction of repaglinide escaping metabolism by the gut (F_G) (C) and by the liver (F_H) (D). Low, medium and high hepatic CYP3A4 expression relate to abundances of <100, 100–199 and ≥200 pmol mg^–1 in microsomal protein, respectively. Blue and red boxes represent simulation of individuals assuming no correlation and correlation between CYP3A4 and CYP2C8, respectively. Closed circles indicate outliers that are beyond the quartiles by one‐and‐a‐half interquartile range