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. 2018 Mar 6;84(5):972–986. doi: 10.1111/bcp.13533

Figure 7.

Figure 7

Coefficients of variation (CVs) in predicted oral clearance (CLoral), AUC ratio and C max ratio (DDI/control) of repaglinide for 10 to 100 trials in 10 virtual individuals generated assuming no correlation (dotted blue line and circles) and correlation between hepatic CYP3A4 and CYP2C8 (solid red line and circles)