Table 1.
Summary of input population parameters
| Simcyp default | CYP3A4–CYP2C8 correlation | Comments | |
|---|---|---|---|
| Demographic | |||
| CYP phenotype | |||
| CYP3A5 EM frequency | 0.17 | 1.00 | CYP2C8 EM frequency |
| Liver | |||
| CYP enzyme abundance | |||
| CYP2C8 mean (pmol mg –1 ) | 24 | 24 | |
| CYP2C8 CV (%) | 81 | 81 | |
| CYP3A4 mean (pmol mg –1 ) | 137 | 137 | |
| CYP3A4 CV (%) | 41 | 41 | |
| CYP3A5 mean (pmol mg –1 ) | Predicted | Predicted | Substituted by CYP2C8 |
| CYP3A5 CV (%) | Predicted | Predicted | Substituted by CYP2C8 |
| Enzyme correlation | |||
| Baseline | 62.775 | 0.771 | Substituted by CYP3A4‐CYP2C8 correlation |
| Slope | 0.3934 | 0.266 | |
| CV (%) | 24 | 47 | |
| Gastrointestinal tract | |||
| CYP enzyme abundance | |||
| CYP3A4 mean (pmol mg –1 ) | 66.2 | 66.2 | |
| CYP3A4 CV (%) | 60 | 60 | |
| CYP3A5 mean (pmol mg –1 ) | 24.6 | 0 | Substituted by CYP2C8 |
| CYP3A5 CV (%) | 60 | 0 | Substituted by CYP2C8 |
CV, coefficient of variation