Illustration of manual delineation for quantification of apparent diffusion coefficient-normal appearing white matter (ADC-NAWM) (A), ADC-tumor (ADC-T) (B), ADC-edema (ADC-E) (C), tumor volume (Vol-T) (D), edema volume (Vol-E) (E), cerebral blood flow-NAWM (CBF-NAWM) (F), CBF-tumor (CBF-T) (G), cerebral blood volume-NAWM (CBV-NAWM) (H), CBV-tumor (CBV-T) (I), fractional anisotropy-NAWM (FA-NAWM) (J), FA-tumor (FA-T) (K), FA-edema (FA-E) (L), CBF-edema (CBF-E) (M), and CBV-edema (CBV-E) (N).