SIN inhibits TNF-α, IL-1β, and IL-6 expression in IP rats. (A, B) Protein/mRNA expression of TNF-α; (C, D) Protein/mRNA expression of IL-1β; (E, F) Protein/mRNA expression of IL-6. Saline: rats were injected with 100 μl saline only; Saline+SIN: rats were injected with 30 mg/kg SIN and 100 μl saline; CFA: rats were injected with 100 μl CFA only; CFA+SIN: rats were injected with 30 mg/kg SIN and 100 μl CFA. * p<0.05 vs Saline group; # <0.05 vs. CFA group.