Skip to main content
. 2018 Jan 5;9(8):2195–2211. doi: 10.1039/c7sc04675h

Table 7. The competitive reaction of Grignard reagents.

Inline graphic
Entry R k X/kH Total yield (%) a
1 H (2j) 36
2 Cl (2p) 1.12 25
3 F (2o) b 0.68 34
4 Me (2q) 0.61 46
5 OMe (2r) 0.18 43

aTotal yield of the products at 40 min.

bDue to the difficulty in analysis, the competitive reaction with 2,4-dimethylphenylmagnesium bromide (2q) instead of 2j was performed to give kF/kMe = 1.12 and calculated with kMe/kH = 0.61.