Table 7. The competitive reaction of Grignard reagents.
| |||
Entry | R | k X/kH | Total yield (%) a |
1 | H (2j) | — | 36 |
2 | Cl (2p) | 1.12 | 25 |
3 | F (2o) b | 0.68 | 34 |
4 | Me (2q) | 0.61 | 46 |
5 | OMe (2r) | 0.18 | 43 |
aTotal yield of the products at 40 min.
bDue to the difficulty in analysis, the competitive reaction with 2,4-dimethylphenylmagnesium bromide (2q) instead of 2j was performed to give kF/kMe = 1.12 and calculated with kMe/kH = 0.61.