. Author manuscript; available in PMC: 2018 Apr 17.

Published in final edited form as: Int J Biochem Cell Biol. 2017 Oct 16;92:202–209. doi: 10.1016/j.biocel.2017.10.006

Table 1.

Inhibitory potency (IC₅₀) of coronaridine congeners at hα4β2 and ha7 AChRs determined by Ca²⁺ influx assays.

Congener	hα4β2		hα7		hα4β2/hα3β4^c (x-fold)	hα7/hα3β4^c (x-fold)
Congener	IC₅₀, μM^a	n_H^b	IC50, μM^a	n_H^b	hα4β2/hα3β4^c (x-fold)	hα7/hα3β4^c (x-fold)
(±)-18-MC	6.3 ± 1.3	1.85 ± 0.17	34.7 ± 5.0	2.21 ± 0.50	4.3	23.6
(+)-Catharanthine	12.6 ± 1.8	1.48 ± 0.25	21.8 ± 2.5	1.43 ± 0.20	18.5	32.0
(±)-18-MAC	20.7 ± 3.0	1.40 ± 0.14	No effect	–	7.9	–
(±)-18-HC	24.8 ± 1.2	1.27 ± 0.06	73.3 ± 10.8	1.64 ± 0.20	8.8	26.1

The Ca²⁺ influx results for hα4β2 and ha7 AChRs were obtained from Figures 2 and 3, respectively.

Hill coefficient.

The calculated ratios were obtained using the data on hα3β4 AChRs previously published (Arias et al., 2015).