Table 3.

Binding affinity of bupropion for the [³H]ibogaine sites at hα3β4 AChRs in the resting and desensitized states.

Resting state [no agonist]		Desensitized state [in the presence of (−)-nicotine]
Ki, μMa	nHb	Ki, μMa	nHb
2.4 ± 0.4	0.72 ± 0.05	1.1 ± 0.1	0.75 ± 0.08

^aThe IC₅₀ values obtained from Fig. 6 were transformed into K_i values using Eq. (1).

^bHill coefficient.