Morphological adaptations in spine subclass (A) volume (Filopodia: *p = 0.0196, Water/Water vs AIE/Water; Long spines: ***p < 0.0001, Water/Water vs AIE/Water, *p = 0.0313, AIE/Water vs AIE/DZ; Stubby spines: ***p < 0.0001, Water/Water vs AIE/Water, *p = 0.046, AIE/Water vs AIE/DZ), (B) diameter (Filopodia: *p = 0.032, Water/Water vs AIE/Water; Long spines: ***p < 0.001, Water/Water vs AIE/Water; **p < 0.01, AIE/Water vs AIE/DZ; Stubby spines: **p < 0.01, Water/Water vs AIE/Water, *p = 0.0176, AIE/Water vs AIE/DZ), and (C) length in adult rats exposed to AIE and DZ (Filopodia: *p = 0.0279, Water vs DZ).