Morphological characteristics of dendritic spine necks after AIE exposure and donepezil post-treatment. Changes in spine neck (A) volume (Filopodia: *p = 0.0221, Water/Water vs AIE/Water; Long spines: **p = 0.0017, Water vs AIE; Stubby spines: *p = 0.073, Water vs AIE), (B) diameter (Filopodia: *p = 0.0161, Water/Water vs AIE/Water; Long spines: ***p = 0.0001, Water/Water vs AIE/Water; **p = 0.0036, AIE/Water vs AIE/DZ; Stubby spines: *p = 0.031, Water vs AIE), and (C) length (Filopodia: *p = 0.0455, Water vs DZ; Long spines: **p = 0.0025, Water/Water vs AIE/Water; **p = 0.0027, AIE/Water vs AIE/DZ; Stubby spines: *p = 0.0203, Water/Water vs AIE/Water; Mushroom: *p = 0.047, Water vs DZ) in dentate gyrus granule neurons.