Figure 1.

Immunohistolocalization of DLX5 in normal endometrium and ovarian endometriosis.

Notes: In healthy endometrium, DLX5 protein is detected in glandular epithelia (A, A′, B, and B′). During the proliferative phase (A and A′), the protein is present both in epithelial nuclei and in the cytoplasm. In contrast, during the secretory phase (B and B′) DLX5 presents a polarized distribution in the cytoplasm and is virtually absent from the nuclei. In ovarian endometriosis implants (C–E′), the expression of DLX5 is more variable. Most of the implants present very few glands with a very large lumen and a thin cuboidal epithelia, which is in general constituted by a mixture of DLX5-positive and DLX5-negative (arrows in E′) cells. Scale bar: (A and B) 250 µm; (C–E) 125 µm; and (A′, B′, C′, D′, and E′) 25 µm.