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. 2018 Apr 11;13:1135–1144. doi: 10.2147/COPD.S161257

Figure 4.

Figure 4

Inhibition of p38 MAPK and ERK reduced the release of MMP-9, but not TIMP-1, from AMs from smokers.

Notes: AMs from AHR − NS (n=8) or AHR + NS (n=8) were incubated in the presence of SB203580 10 μM (p38 MAPK inhibitor) (A) or PD98059 30 μM (MEK1/2 inhibitor) (B) for 24 h. The release of MMP-9 and TIMP-1 in the culture supernatants was determined by enzyme-linked immunosorbent assays. *P<0.05 compared to untreated controls. AHR − S, smokers without AHR; AHR + S, smokers with AHR.

Abbreviations: AHR, airway hyperresponsiveness; AMs, alveolar macrophages; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; MEK, MAPK kinase; MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor of metalloproteinase-1.