A, Effects of telenzepine on phosphorylation and expression of ERK1/2 in the CPu. B, Effects of telenzepine on phosphorylation and expression of ERK1/2 in the NAc. Representative immunoblots are shown to the left of the quantified data. Note that insignificant changes in pERK2 signals were seen following telenzepine injection in both the CPu (F(1,12) = 0.791, P = 0.391) and NAc (F(1,12) = 0.017, P = 0.899). Rats were given an i.p. injection of saline (Sal) or telenzepine (Tel) at 3 mg/kg and were sacrificed 15 or 30 min after drug injection for Western blot analysis of changes in pERK1/2 and ERK1/2 expression. Data are presented as means ± SEM (n = 4 per group).