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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2018 Apr;11(4):e005682. doi: 10.1161/CIRCEP.117.005682

Figure 6. NADPH oxidase activity is required for aberrant ox-CaMKII, heart rhythms, and calcium handling in mdx mice.

Figure 6

(A) Quantification of Western blots demonstrating ox-CaMKII level in mdx mice in which the NADPH oxidase 2 (Nox2) subunit p47phox was absent (mdx:p47−/−). (B) Incidence of ventricular tachycardia (VT) following programmed electrical stimulation in mdx and mdx:p47−/− mice. (C) Reduced Ca2+ spark frequency in myocytes from mdx:p47−/− mice compared to mdx. *P<0.05, **P<0.01, ***P<0.001.