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. Author manuscript; available in PMC: 2018 Apr 17.
Published in final edited form as: J Am Coll Cardiol. 2018 Apr 3;71(13):1459–1470. doi: 10.1016/j.jacc.2018.01.060

FIGURE 1. Binge Alcohol Increases the Inducibility of Atrial Arrhythmia in the Human Donor Heart and Rabbit Heart.

FIGURE 1

(A) Representative electrogram trace showing burst pacing (3 Hz)-induced AF in a binge alcohol-exposed human donor heart (with normal cardiac function). (B) Representative EG recording from a paced age-matched control human donor heart and there was no AF upon cessation of pacing. (C) Representative electrogram trace showing burst pacing (for 30 s at 6× diastolic threshold; cycle length = 100 ms)-induced AF immediately after cessation of the pacing in open-chest rabbits with binge alcohol pre-exposure, whereas the same burst pacing protocol did not induce any incidence of atrial arrhythmia in sham control rabbit. (D) Summarized data showing enhanced AF inducibility and increased average duration of pacing-induced AF in binge alcohol-exposed rabbits compared to that of sham controls. AF = atrial fibrillation; Alc = alcohol; EG = electrogram; NSR = normal sinus rhythm.