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. Author manuscript; available in PMC: 2018 Apr 17.
Published in final edited form as: J Am Coll Cardiol. 2018 Apr 3;71(13):1459–1470. doi: 10.1016/j.jacc.2018.01.060

FIGURE 3. JNK Inhibition Precludes Binge Alcohol-Evoked Atrial Arrhythmogenicity in Intact Mouse Atria.

FIGURE 3

(A) Representative electrogram traces showing burst-pacing induced atrial arrhythmia in a Langendorff-perfused WT mouse heart with binge alcohol pre-exposure (1.), and self-restored NSR after burst pacing in sham control mouse hearts (2.) as well as binge alcohol-exposed JNK1/2dn mouse hearts with overexpression of cardiac-specific inactivated dominant negative JNK (3.). (B, C) Summarized data of enhanced AF inducibility and increased average duration of pacing-induced AF in binge alcohol-exposed WT mouse hearts compared to that of sham controls. JNK1/2dn = inactivated dominant negative JNK1 and JNK2; other abbreviations as in Figures 1 and 2.