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. Author manuscript; available in PMC: 2018 Apr 17.
Published in final edited form as: J Am Coll Cardiol. 2018 Apr 3;71(13):1459–1470. doi: 10.1016/j.jacc.2018.01.060

FIGURE 6. Like the Effect of JNK2 Inhibition, CaMKII Inhibition Also Abolishes This Binge Alcohol-Evoked Abnormal Ca2+ Handling in Atrial Myocytes and Intact Atria.

FIGURE 6

(A) Summarized data showing CaMKII inhibition with the inhibitor KN93 (but not its inactive analog KN92) also prevented alcohol-evoked tetracaine-sensitive diastolic SR Ca2+ leakage in HL-1 myocytes. (B) (C) In vivo treatment with a single dose of KN93 eliminated alcohol-evoked Ca2+ waves and shortened [Ca2+]i decay constant τ compared to KN92-treated alcohol hearts. Abbreviations as in Figure 1.