Table 4. Comparison of the primary outcome, treatment failure at 1 week, between treatment arms.

Primary outcome definition	Arm		Difference	Upper limit 95% CI	p-Value
	Conditional, n (percent)	Universal, n (percent)
Treatment failure 1 (danger sign, hospital admission, death, malaria, pneumonia, diarrhoea, or reported fever)
Per-protocol	16 (0.80)	90 (4.61)	−3.81%	0.65	0.002
Intention-to-treat	19 (0.89)	94 (4.57)	−3.67%	0.57	0.002
Treatment failure 2 (danger sign, hospital admission, death, malaria, pneumonia, diarrhoea, or reported fever ≥3 days)
Per-protocol	12 (0.60)	25 (1.28)	−0.68%	0.43	<0.001
Intention-to-treat	12 (0.56)	29 (1.41)	−0.847%	0.18	<0.001
Treatment failure 3 (danger sign, hospital admission, death, malaria, pneumonia, diarrhoea, or measured fever [≥37.5°C])
Per-protocol	10 (0.50)	14 (0.72)	−0.22%	0.42	<0.001
Intention-to-treat	10 (0.47)	17 (0.83)	−0.36%	0.27	<0.001
Treatment failure 4 (danger sign, hospital admission, death, malaria, pneumonia, or diarrhoea)
Per-protocol	7 (0.35)	3 (0.15)	0.20%	0.55	<0.001
Intention-to-treat	7 (0.33)	6 (0.29)	0.03%	0.36	<0.001