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. 2018 Apr 17;13(4):e0195946. doi: 10.1371/journal.pone.0195946

Table 4. The numbers of neovascularization and macrophage infiltrate in the herniated disc (n = 60).

CD34 (+) p value CD68 (+) p value
Age (years)
    <50 (n = 26) 13.74 ± 3.87 15.48 ± 3.82
    ≥50 (n = 34) 14.52 ± 3.43 0.411 17.34 ± 3.57 0.056
Herniation type
    TE (n = 41) 12.68 ± 3.57 16.88 ± 3.72
    S (n = 19) 14.34 ± 3.28 0.102 16.16 ± 3.41 0.437
Disease duration (weeks)
    9–12 (n = 40) 12.55 ± 3.34 15.13 ± 3.83
    13–16 (n = 20) 14.34 ± 3.96 0.071 17.16 ± 3.54 0.052
Modic changes
    + (n = 23) 12.74 ± 3.55 14.68 ± 3.29
    − (n = 37) 14.62 ± 3.67 0.06 16.97 ± 3.97 0.019
Cartilaginous endplate
    + (n = 25) 8.24 ± 3.36 9.32 ± 3.29
    − (n = 35) 16.26 ± 3.67 < 0.001* 19.82 ± 3.67 <0.001*

mean ± SD.

TE; transligamentous extrusion, S; sequestration.

*Statistically significant (with Bonferroni correction, significance is set at p < 0.005).