Table 1. Investigations recommended for work-up of PUO in the clinical guideline [1] with modifications.
The total cost for each line of investigations are shown in Singapore dollars (SGD).
| Investigations | Total cost |
|---|---|
| First-line (non-specific) investigations | SGD 826.30 |
| Complete blood count with differential | |
| Electrolyte panel | |
| Liver function tests | |
| Gamma-glutamyl transferase | |
| Blood cultures x 3 | |
| Urine dipstick | |
| Urine microscopy | |
| Urine cultures | |
| Erythrocyte sedimentation rate | |
| Quantiferon test for tuberculosis | |
| Chest radiography | |
| Second-line investigation | SGD 850.00 |
| Computed tomography scan of abdomen and pelvis | |
| Third-line (disease-specific) investigations | |
| Infectious diseases | SGD 433.00 |
| Urine culture | |
| Sputum culture and gram stain | |
| Sputum culture for tuberculosis | |
| VDRL | |
| Epstein-Barr virus IgG | |
| Epstein-Barr virus IgM | |
| Cytomegalovirus IgG | |
| Cytomegalovirus IgM | |
| Human immunodeficiency virus serology | |
| Antistreptolysin-O antibodies titer | |
| Malignancies (hematological) | SGD 56.10 |
| Peripheral blood smear | |
| Serum protein electrophoresis | |
| Malignancies (solid tumor) | SGD 2840.00 |
| Bone scan | |
| Mammography | |
| Chest CT with contrast | |
| Positron emission tomography scan | |
| Autoimmune disease | SGD 40.00 |
| Rheumatoid factor | |
| Antinuclear antibodies | |
| Miscellaneous | SGD 158.20 |
| Thyroid studies | |
| Angiotensin-converting enzyme levels (ACE) | |
| Unresolved diagnosis | SGD 3527.30 |
| Sum of costs for all third-line, disease-specific investigations above |