Fig 6. CNO treatment alone does not alter cognitive flexibility.

Despite being thought of as an inert synthetic ligand, recent evidence suggests that CNO can activate endogenous receptors and have behaviorally relevant effects. To rule out the possibility that CNO treatment itself affects performance on the ASST, non-infected control rats (n = 6) were injected with CNO or saline 20 min prior to the completion of the extradimensional shift (EDS). a,b. There were no differences in number of trials to reach criterion or number of errors made between CNO- and saline-treated rats.