Figure 6.

Schematic diagram summarising the biological processes underlying the association of the 35‐gene expression signature with PTEN/AKT signalling pathways. Notably, PKR has been reported to be important for the tumour suppressive activity of PTEN, independent of the PI3K/AKT signalling pathway 42. We hypothesized that this could be modulated by several genes within our gene signature. TPT1 has been previously reported to modulate the expression of PKR 40. Apart from TPT1, actins and troponin‐associated factors from the 35‐gene expression signature (TPM2, ACTA2, and ACTG2) were also reported to induce the activation of PKR. The dotted lines in the diagram thus signify biological associations between genes within our signature and its possible association with PKR that warrant further investigation.