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. 2018 Feb 16;50(2):e445. doi: 10.1038/emm.2017.271

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effects of ISO-1 on migration inhibitory factor (MIF) and monoamine content in L-SC and VTA following chronic constriction injury (CCI). The MIF inhibitor ISO-1 was administered i.t. or i.c.v. for 2 weeks from day 7 post-nerve injury. In L-SC and VTA, the MIF and monoamine content was detected with ELISA and HPLC, respectively, at post-injury day 21. The turnover effect of i.t. ISO-1 for MIF and dopamine in L-SC is shown in a and b (*P<0.05 vs normal mice; ^†P<0.05 vs CCI mice). In VTA, a similar turnover phenomenon of i.c.v. ISO-1 regarding MIF and dopamine was also observed (d, e, *P<0.05 vs normal mice; ^†P<0.05 vs CCI mice). Data are shown as the means±s.e.m.’s and were analyzed with one-way ANOVA. N=15 in each group. Then, correlation analysis clearly showed an obvious non-linear, negative relationship between MIF and dopamine in L-SC and VTA in sham, CCI, or CCI+ISO-1 mice (c, f). C, CCI; CI, CCI+ISO-1; L-SC, lumbar spinal cord L5-6; N, normal; VTA, ventral tegmental area.