Table 5. The efficacy of Bismuth plus Furazolidone- or Clarithromycin-containing quadruple therapies for H. pylori eradication .
Year | City | Therapy |
Treatment duration
(days) |
Number of
patients. |
Underlying disease | Eradication assessment method. |
Duration from therapy
(week) |
Per-protocol eradication rate |
2007 | Isfahan50 | OABF | 7 | 78 | H. pylori (+) | UBT | 4 | 84.8 |
2010 | Tehran28 |
OABM-F OABC-F |
10 (M: 5, F: 5, C: 5) |
103 103 |
PUD | UBT | 8 |
91.3 88.7 |
2015 | Sari38 |
OABF OABM-F |
10 (M: 5, F: 5) |
120 120 |
PUD | UBT | 8 |
86.6 82.5 |
2000 | Tehran46 | RABF | 14 | 53 | DU | UBT | 4 | 82 |
2001 | Tehran51 | OABF | 14 | 63 | DU | UBT | 12 | 90 |
2004 | Sari40 |
OABF (F: 100 BID) OABF (F: 200 BID) |
14 14 |
50 50 |
DU | UBT | 12 |
72 92 |
2007 | Isfahan50 | OABF | 14 | 78 | H. pylori (+) | UBT | 4 | 82.6 |
2007 | Tehran45 |
OABF OABF-M |
14 (F: 7, M: 7) |
104 103 |
PUD | UBT | 8 |
95.2 95.3 |
2009 | Shiraz34 | OABF | 14 | 69 | H. pylori (+) | UBT | 4-6 | 56 |
2011 | Ghom41 | OABF | 14 | 43 | H. pylori (+) | UBT | 12 | 85.3 |
2012 | Sari40 | OABF | 14 (F: 7) | 80 | PUD | UBT | 12 | 90.2 |
2012 | Sari56 | OABF | 14 (F: 7) | 124 | PUD | UBT | 8 | 88.7 |
2015 | Tehran53 | OABC | 10 | 60 | H. pylori (+) | UBT | 8 | 65.2 |
2001 | Tehran49 |
OBCT (C: 250 BID) |
14 | 73 | DU | UBT | 8 | 88 |
2001 | Tehran51 | OABC | 14 | 55 | DU | UBT | 12 | 90 |
2013 | Isfahan54 |
OABC OABC + probiotic |
14 | 90 | PUD | UBT | 4 |
82.1 84.4 |
O: Omeprazole, R: Ranitidine, Amox: Amoxicillin, B: Bismuth subcitrate, Tetra: Tetracycline, M: Metronidazole, C: Clarithromycin, F: Furazolidone, DU: Duodenal ulcer, PUD: Peptic ulcer disease, UBT: Urea breath test, BID: twice daily