Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: FEBS Lett. 2018 Feb 22;592(7):1063–1078. doi: 10.1002/1873-3468.12999

Figure 1. Step-wise oligodendrocyte lineage differentiation process.

Figure 1

The linage specification and progression from NSCs unfolds in distinct stages at different regions from primitive oligodendrocyte progenitor cells (pri-OPCs) also called uncommitted OPCs (Olig1/2+/A2B5+/PDGFRαlow) to committed OPCs (PDGFRαhigh/NG2+) to differentiating immature oligodendrocytes (O4+/CNP+) to differentiated oligodendrocytes (CC1+) and finally to mature myelinating oligodendrocytes (e.g. MBP+/PLP+/MOG+).