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Antibodies use less charged residue and less hydrophobic residues in protein-protein interaction. Amino acid interaction propensities at different cutoff distances for protein-protein interactions. A. 5 Å; B. 3.5 Å; and C. 3.0 Å. Blue bar: Non-antibody proteins-protein interactions, red bar: Antibody amino acids in antibody-protein antigen interactions.
