Skip to main content
. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Anesthesiology. 2018 May;128(5):967–983. doi: 10.1097/ALN.0000000000002063

Figure 3.

Figure 3

Inoculation with hsvMOR, hsvPPE or hsvMOR + PPE increases the number of Enkephalin (Enk-ir) and co-labeled mu-opioid receptor (mOR)-ir and green fluorescent protein-positive dorsal root ganglion cells. A. Quantification of Enk-ir positive DRGs on Day 16 post viral inoculation. There is a significant increase in Enk-ir in hsvPPE and hsvMOR + PPE treatment groups compared to sham and control virus (hsvCON, hsvCON (two-way ANOVA, factors: group × neuron size, F(12, 60) = 7.5, P <0.001). Bottom: Histology images of Enk+ dorsal root ganglion with control virus (left) and hsvPPE (right). B. Quantification of MOR-ir positive DRGs on Day 16 post viral inoculation. Bottom: Histology images of MOR+ dorsal root ganglion with control virus (left) and hsvMOR (right). There is a significant increase in MOR-ir in large and medium sized DRGs of hsvMOR, hsvPPE and hsvMOR + PPE treatment groups compared to sham and control virus (hsvCON, two-way ANOVA, factors: group × neuron size, F(12, 60) = 10.5, P < 0.001). # vs. sham; # significant at P<0.05; ## significant at P<0.01; ### significant at P<0.001. * vs. control virus-treated (hsvCON);* significant at P<0.05; ** significant at P<0.01; *** significant at P<0.001.

Bonferroni post-hoc for multiple comparisons.