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. 2017 Nov 28;5(3):223–237. doi: 10.1016/j.jcmgh.2017.11.011

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Inhibition of taurocholate uptake by ASBT after treatment with compounds. (A–F) Intracellular taurocholic acid values in MDCKII cells expressing ASBT after a 2-minute uptake after treatment with the following: (A) bifonazole, (B) bromhexine hydrochloride, (C) clofazimine, (D) lovastatin, (E) meclozine dihydrochloride, and (F) simvastatin. Data are normalized as a percentage from control (dimethyl sulfoxide [DMSO], 100% is control) and are represented as means ± SD. Data are from a representative experiment replicated 2 times (n = 3). *P < .05, **P < .01, and ***P < .001 (1-way analysis of variance; post hoc: Dunnett multiple comparison).