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. 2017 Nov 28;5(3):223–237. doi: 10.1016/j.jcmgh.2017.11.011

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Oral clofazimine administration results in increased intracellular bile acid concentrations in ileal enterocytes. (A–D) Eight-week old mice were orally administered placebo, 25 mg/kg clofazimine, or 250 mg/kg clofazimine solved in corn oil followed by a cholecystokinin octapeptide injection (50 ng/kg). After 6 hours, mice were killed and mRNA levels were measured in the distal part of the ileum. Gene expression of (A) Ibabp, (B) Fgf15, (C) Ostα, and (D) Ostβ were measured. Values were normalized to Hypoxanthine-guanine phosphoribosyltransferase and 36B4 and expressed as arbitrary units. Data are represented as means ± SD (n = 13). *P < .05, **P < .01, and ***P < .001 (1-way analysis of variance; post hoc: Dunnett multiple comparison).